Aesthetics · Regeneration · Longevity
    The 23MD Journal
    Vol. VII · MMXXVI

    Reviewed by the doctors who deliver it.

    Dr Suha Kersh giving an injectable treatment to a patient's cheek at 23MD
    Skin boosters and fillers do different jobs; Dr Kersh decides which, if either, at consultation.
    Aesthetics

    Skin booster vs filler: what's the difference?

    Medically reviewed by Dr Suha Kersh, Co-Founder & Director of Cosmetic Medicine · Published 26 October 2026 · Last reviewed 26 October 2026

    Quick answer: A skin booster and a filler do different jobs. A skin booster places a fine hyaluronic acid gel within the skin to improve hydration, smoothness and texture; it is not designed to add volume. A dermal filler places a firmer gel beneath the skin to restore volume and structure. Some people suit one, some both, and some neither.

    Questions about your own situation? Message our team on WhatsApp: London · Dubai

    What is the difference between a skin booster and a filler?

    The difference between a skin booster and a filler comes down to depth and purpose. Both usually contain hyaluronic acid, a molecule the body makes naturally that attracts and holds water. What differs is how the gel is made, where it goes and what it is for.

    A skin booster is injected into the dermis, the living layer of the skin, as many tiny micro-injections. A 2024 review in Archives of Plastic Surgery describes skin boosters as aimed at skin quality (hydration, radiance and texture) rather than volume [1].

    A dermal filler is placed deeper, beneath the skin or close to bone, to replace lost support or soften a deep fold. Put simply, a dermal filler works on the shape of the face; a skin booster works on the skin covering it.

    Is a skin booster better than filler?

    A skin booster is not better or worse than filler, because the two treat different concerns. Skin that looks dull, dry, crêpey or finely lined, while the face shape has barely changed, points towards a skin booster. Flattening in the cheeks, hollowing or lost definition is what filler addresses, and a skin booster will not.

    The evidence differs too. A 2025 systematic review and meta-analysis of midface filler pooled five randomised controlled trials (748 participants): hyaluronic acid filler clearly outperformed control groups for visible improvement, with adverse events rarely reported, though the authors called the evidence limited [2].

    For skin boosters, the 2024 review found cross-linked hyaluronic acid (a more stable form) improved roughness when injected into the skin, while non-cross-linked versions were less consistent; controlled studies are few [1].

    Do skin boosters add volume?

    Skin boosters do not add meaningful volume and are not designed to change the shape of the face. The gel is spread thinly through the dermis, so skin looks better hydrated and smoother rather than fuller. One study found hyaluronic acid placed within the skin improved texture, while the same type placed beneath it did not [1].

    So a skin booster cannot replace filler where support has been lost. Lines that appear only when you move your face, such as frown lines, come mainly from muscle activity and need a separate conversation with your doctor.

    How long do skin boosters last?

    Skin booster results usually fade over several months, varying with product, area and person. In one study of 131 adults, an intradermal hyaluronic acid gel improved cheek roughness in 76% of treated cheeks at four months, falling to 35% at six months, while measured skin hydration stayed above baseline for nine months [3]. That study had no comparison group and was funded by the product's manufacturer, so its figures should be read with care [3].

    Skin boosters are usually given as a short course, then maintenance. Filler is a firmer gel placed deeper and tends to last longer, but the body gradually breaks it down too. Your doctor will plan reviews rather than promise a fixed duration.

    Can you have skin boosters and filler together?

    Skin boosters and filler can be combined, because they work at different depths on different concerns. The 2024 review describes combining boosters with other treatments as a common way to enhance results, and advises spacing energy-based device treatments a few weeks from booster injections [1]. Whether combining suits you, and in what order, is decided at consultation.

    You may also hear about polynucleotides, DNA-derived injectables that aim to support the skin's own repair [1]. We look at their evidence in Polynucleotides, examined.

    What about skincare?

    Neither treatment replaces daily care. At 23MD, skin quality is also addressed with 23MD Skin Medicine, a range of five face creams matched to your skin and selected by a doctor after consultation. For many patients, a well-chosen cream is where we start before anything injectable.

    How do skin boosters and fillers compare?

    Skin boosterDermal filler
    Main purposeHydration, smoothness, fine textureVolume, structure, contour
    Where it goesWithin the skin (dermis), as many micro-injectionsBeneath the skin or near bone, in targeted points
    Typical planA short course, then maintenance; protocols vary [1]Often one appointment with a review; repeated as the gel breaks down
    How long it lastsMonths; one study showed texture fading by six months and hydration lasting to nine [3]Varies with product and area; usually longer than a skin booster
    Strength of evidenceModerate: reviews and small trials, many industry-funded [1][3]Stronger: systematic review of randomised trials [2]
    Can it be reversed?Usually fades on its ownHyaluronic acid filler can be dissolved with hyaluronidase [4]

    Are there side effects?

    Both are medical procedures with risks. Skin boosters commonly cause mild, short-lived redness, swelling, bruising and needle marks; small bumps occasionally form [1]. Filler commonly causes bruising and swelling, and less often lumps, infection or delayed inflammation [4].

    The most serious filler risk is gel entering or pressing on a blood vessel, which can damage skin and, rarely, affect vision. An expert consensus panel stresses stopping the injection at once if this is suspected, and that thorough knowledge of facial anatomy is central to prevention [4].

    The 23MD view

    "My first question at consultation isn't what you'd like to change; it's what you like about your face. That tells me what to protect. Skin boosters and filler are tools, and I often find the skin needs attention before anyone thinks about volume. Through Treatment Stacking, I look at skin, lines, volume and bone together, aiming to rebalance the face rather than take it over. Sometimes that means one treatment, sometimes a combination, and sometimes nothing injectable at all." — Dr Suha Kersh

    Not sure whether your skin, your volume or both are the priority? Explore your options with our Skin Expert. It suggests treatments to discuss at consultation, based on your concerns and an optional photo. It gives general information only and does not diagnose or replace a doctor.

    Who this is for, and who it isn't for

    • May be worth discussing a skin booster: adults whose skin looks drier, duller or more finely lined than it used to.
    • May be worth discussing filler: adults noticing loss of volume or definition.
    • Not for: anyone hoping to look like someone else.
    • Not suitable without medical advice: people who are pregnant or breastfeeding, have active infection in the area, or have had reactions to hyaluronic acid or local anaesthetic. Your doctor reviews your medical history first.

    Frequently asked questions

    Is a skin booster just a weaker filler? No. Both often use hyaluronic acid, but a skin booster is placed within the skin to improve hydration and texture, while filler is placed beneath it to add volume and support [1].

    Will a skin booster make my face look fuller? A skin booster is not designed to add volume. Any change is in how the skin looks and feels, not in the shape of the face [1].

    How many skin booster sessions are usually needed? Usually a short course, then maintenance. Protocols are not standardised, so your doctor suggests a plan [1].

    Can filler be dissolved? Hyaluronic acid filler can usually be dissolved with an enzyme called hyaluronidase if needed [4].

    Talk to a 23MD doctor

    Unsure which approach fits what you are noticing? Your first consultation lasts 45 to 60 minutes. Suitability and results vary, and your doctor will discuss benefits and risks, including whether treatment is right for you at all.

    23MD is a doctor-led clinic in Chelsea, London (since 2015) and Jumeirah 1, Dubai (since 2023).

    References

    1. Rho NK, Kim HS, Kim SY, Lee W. Injectable "Skin Boosters" in Aging Skin Rejuvenation: A Current Overview. Archives of Plastic Surgery. 2024;51(6):528–541. https://pmc.ncbi.nlm.nih.gov/articles/PMC11560330/
    2. Safia A, Abd Elhadi U, Merchavy S, Batheesh R, Bathish N. Efficacy and Safety of Hyaluronic Acid Fillers for Midface Augmentation: A Systematic Review and Meta-Analysis. Medicina. 2025;61(10):1823. https://www.mdpi.com/1648-9144/61/10/1823
    3. Niforos F, Ogilvie P, Cavallini M, et al. VYC-12 Injectable Gel Is Safe and Effective for Improvement of Facial Skin Topography: A Prospective Study. Clinical, Cosmetic and Investigational Dermatology. 2019;12:791–798. https://www.dovepress.com/vyc-12-injectable-gel-is-safe-and-effective-for-improvement-of-facial--peer-reviewed-fulltext-article-CCID
    4. Urdiales-Gálvez F, Escoda Delgado N, Figueiredo V, et al. Treatment of Soft Tissue Filler Complications: Expert Consensus Recommendations. Aesthetic Plastic Surgery. 2018;42(2):498–510. https://pmc.ncbi.nlm.nih.gov/articles/PMC5840246
    23MD

    23MD is a doctor-led centre for aesthetics, wellness and digital care in London and Dubai, bringing together aesthetic medicine, hormonal and metabolic health, regenerative care and AI-supported medicine under one clinical standard.

    Aesthetics · Regeneration · Longevity© 2026 23MD. 23MD London is operated by 23MD Medical Services Ltd; 23MD Dubai by 23MD Clinic L.L.C.
    Book a Consultation

    Choose your hub

    As featured in

    Featured In
    The Times
    GQ Middle East
    Tatler
    Vogue Arabia
    Khaleej Times
    Financial Times
    Emirates Woman
    Daily Mail
    Harper's Bazaar