Skin regeneration, from the inside.
Polynucleotides
A doctor-led regenerative injectable that supports the skin at a cellular level. We hold a range of brands, including Ameela and Plinest, and select the right one for you.
Regenerative Injectables · London & Dubai (Ameela: London only)
The Treatment
Polynucleotides
Polynucleotides are a regenerative treatment that works on the quality of the skin itself, not on its shape. Rather than adding volume or smoothing lines, they help the skin behave like younger skin again: thicker, more elastic, more hydrated. At 23MD, we hold a range of specific brands within the polynucleotide family and select the right one for you.
Some changes don't respond to fillers or lines & wrinkles treatment. Crepey skin under the eyes, thin skin on the neck, a generally tired or fragile quality, these are problems of skin biology, not shape. Polynucleotides are one of the few treatments that address them directly. The clinical decision is rarely 'polynucleotides yes or no', it is which polynucleotide, in which area, as part of which protocol.
Duration
30–45 min
Downtime
24–48 hrs
Pain level
Low
Sessions
2–3 sessions, then 6–12 months
Results start
After 1st session
Results peak
4–8 weeks
About
What it is, how it works.
How it works
Tiny amounts are placed just beneath the skin's surface in the area being treated. Over the following weeks, they support the skin's own repair cells to work more actively. Different polynucleotide products have different molecular profiles, Ameela is particularly well-suited to delicate areas such as under the eye; Plinest is more commonly chosen for broader facial skin-quality work.
Why it matters
Some changes don't respond to fillers or lines & wrinkles treatment. Crepey skin under the eyes, thin skin on the neck, a generally tired or fragile quality, these are problems of skin biology, not shape. Polynucleotides are one of the few treatments that address them directly. The clinical decision is rarely 'polynucleotides yes or no', it is which polynucleotide, in which area, as part of which protocol.
Indications
What We Treat
- Thinning or crepey skin
- Loss of skin elasticity
- Under-eye skin quality (typically Ameela)
- Broader facial skin-quality concerns (typically Plinest)
- Fine lines not addressed by lines & wrinkles treatment
- Skin laxity in the neck and décolletage
- Dull or fatigued-looking skin
Practitioners
Your Experts
Treatment Stacking™
Combines beautifully with
Results & Expectations
Clinical Expertise. Natural Outcomes.
What may improve
- Skin elasticity and resilience
- Hydration and overall skin tone
- Texture and surface smoothness
- Quality of skin in delicate areas (eyes, neck, décolletage)
Timeline
Subtle improvement after the first session, with cumulative gains. Peak outcomes typically 4–8 weeks after completing the course.
Polynucleotides improve skin quality progressively, they do not deliver immediate visible volume change.
Meet our 23MD Digital Team
Doctor-led intelligence, at your fingertips. Explore your skin or plan how Polynucleotides layers with the rest of your protocol.
Skin Expert
AI-led skin assessment
Upload a photo and receive a personalised skin assessment with treatment recommendations from our doctor-led protocols.
Analyse My Skin
Treatment Stacker
What should I actually do?
Tell it your goal, timeline and clinic, and it drafts a sequenced plan — system, structure, surface — built on the 23MD Treatment Stacking™ method, for a 23MD doctor to review.
Draft My Stack23MD Digital tools provide general information only and do not replace a consultation with a doctor. In an emergency, contact your local emergency services.
Suitable For
Safety & Suitability
Not suitable for
- Pregnancy or breastfeeding
- Active skin infection at the treatment area
- Known hypersensitivity to fish-derived products
- Certain autoimmune conditions (assessed at consultation)
- Active inflammatory skin disease in the treatment area
Consultation required: A medical consultation is required to confirm suitability, define the course, and select the right product for your skin.
FAQs
Your Questions, Answered
Polynucleotides are a regenerative injectable that supports your skin's own repair processes, improving quality, elasticity, and resilience over time rather than adding volume.
Both are leading polynucleotide products with slightly different molecular profiles. Ameela is particularly well-suited to delicate areas such as under the eye. Plinest is more commonly chosen for broader facial skin-quality work.
Plinest is available at both our London and Dubai clinics. Ameela is currently held at our London clinic.
Fillers add structural support and volume. Polynucleotides do not volumise, they improve the quality, elasticity, and resilience of the skin itself.
Subtle improvement is often visible after the first session, with peak results typically 4–8 weeks after the final session.
Minimal. Small injection points may be visible for 24–48 hours, and mild swelling is possible.
Yes. The under-eye area is one of the most common and well-tolerated treatment zones, typically using Ameela.
Medically reviewed by Dr Suha Kersh, MB BCh BAO LRCP&SI, MRCPsych, GMC-registered since 1992.
